Mark G. Clemens, Ph.D.

CBES Area of Interest:

Dr. Clemen’s lab specializes in the regulation of liver microcirculation: Role of stress-inducible vasoactive mediators (endothelin, nitric oxide synthase, hydrogen sulfide, sonic hedgehog, heme oxygenase) in altering vascular responsiveness in the liver following oxidative or inflammatory stress. Mechanisms of control of sinusoid perfusion by hepatic stellate cells, especially related to components of phenotypic transformation in response to injury. His research is also centered around the hepatic metabolic response to infection. Mechanisms of altered carbohydrate metabolism during sepsis, especially related to differentiation between inflammation-induced changes in gene expression and perfusion supply/demand ratio as mediators of decreased gluconeogenesis. The application of imaging techniques to biological research is another important part of Dr. Clemen’s research. It uses the In vivo video microscopy for study of liver microcirculation and an application of quantitative fluorescence techniques in the monitoring of cellular processes in intact organs or in vivo. Engineered liver support systems: Bioengineering Research Partnership.

CBES Area of Expertise:

Regulation of liver microcirculation, hepatic metabolic response to infection, application of imaging techniques to research in biology and engineered liver support systems.