Mahrukh K. Ganapathi, Ph.D.

CBES Area of Interest:

Our research studies in high grade serous ovarian cancer are focused on: a) developing prognostic markers that predict recurrence of high grade serous ovarian cancer, and b) studying the etiology of ovarian cancer in relation to site of origin, i.e. ovary or fallopian tube. Studies in AML are focused on optimizing retinoic acid-induced differentiation therapy, which has been effective for treating a subtype of AML, acute promyelocytic leukemia. In preclinical cell culture studies the combination of retinoic acid with the clinically active topoisomerase 2 inhibitor, dexrazoxane, has proved efficacious. Our laboratory is currently studying the effectiveness of this combination in mouse models with the hope of advancing this therapeutic regimen for clinical testing in AML patients. Further, we are examining the signaling mechanisms involved in this synergistic interaction in different subtypes of AML.

CBES Area of Expertise:

Ovarian cancer genomics; differentiation therapy of acute myeloid leukemia (AML).